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http://purl.uniprot.org/citations/21809360http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21809360http://www.w3.org/2000/01/rdf-schema#comment"

Unlabelled

Tumor cells can move as individual cells in two interconvertible modes: mesenchymal mode and amoeboid mode. Cytoskeleton rearrangement plays an important role in the interconversion. Previously, we reported that HAb18G/CD147 and annexin II are interacting proteins involved in cytoskeleton rearrangement, yet the role of their interaction is unclear. In this study we found that the depletion of HAb18G/CD147 produced a rounded morphology, which is associated with amoeboid movement, whereas the depletion of annexin II resulted in an elongated morphology, which is associated with mesenchymal movement. The extracellular portion of HAb18G/CD147 can interact with a phosphorylation-inactive mutant of annexin II and inhibit its phosphorylation. HAb18G/CD147 inhibits Rho signaling pathways and amoeboid movement by inhibiting annexin II phosphorylation, promotes membrane localization of WAVE2 and Rac1 activation by way of the integrin-FAK-PI3K/PIP3 signaling pathway, and promotes the formation of lamellipodia and mesenchymal movement.

Conclusion

These results suggest that the interaction of HAb18G/CD147 with annexin II is involved in the interconversion between mesenchymal and amoeboid movement of hepatocellular carcinoma cells."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.org/dc/terms/identifier"doi:10.1002/hep.24592"xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Huang W."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Li Y."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Zhang W."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Tang J."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Zhao P."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Wang S.J."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Zhang S.H."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Tavernier J."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Chen Z.N."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Jiang J.L."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Yu X.L."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Guo Y.S."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/author"Cui H.Y."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/name"Hepatology"xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/pages"2012-2024"xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/title"HAb18G/CD147 promotes cell motility by regulating annexin II-activated RhoA and Rac1 signaling pathways in hepatocellular carcinoma cells."xsd:string
http://purl.uniprot.org/citations/21809360http://purl.uniprot.org/core/volume"54"xsd:string
http://purl.uniprot.org/citations/21809360http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21809360
http://purl.uniprot.org/citations/21809360http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21809360
http://purl.uniprot.org/uniprot/#_A0A024R5Z7-mappedCitation-21809360http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21809360
http://purl.uniprot.org/uniprot/#_A0A346REH8-mappedCitation-21809360http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21809360
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