| http://purl.uniprot.org/citations/21810534 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21810534 | http://www.w3.org/2000/01/rdf-schema#comment | "Persistent viral infections can lead to disease such as myocarditis. Theiler's murine encephalomyelitis virus (TMEV) infects macrophages of SJL/J (H-2s) mice establishing persistent infections leading to demyelinating disease. In contrast macrophages from B10.S (H-2s) mice clear TMEV. Activation of the transcription factor IRF3 induces IFNβ, ISG56, and apoptosis for viral clearance, but also inflammatory cytokines, such as IL-23 and IL6, which contribute to disease. Here we identify polymorphisms in the IRF3 of SJL/J versus B10.S mice that are located in DNA binding, nuclear localization, and autoinhibitory domains. SJL-IRF3 expression in RAW264.7 macrophage cells with or without TMEV infection decreased IL-23p19 promoter activity compared with B10S-IRF3. In contrast SJL-IRF3 increased IL-6, ISG56 and IFNβ in response to TMEV. B10S-IRF3 expression augmented apoptotic caspase activation and decreased viral RNA in TMEV-infected macrophages while SJL-IRF3 increased viral replication with less caspase activation. Therefore IRF3 polymorphisms contribute to viral persistence and altered cytokine expression."xsd:string |
| http://purl.uniprot.org/citations/21810534 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2011.06.028"xsd:string |
| http://purl.uniprot.org/citations/21810534 | http://purl.uniprot.org/core/author | "Brown D.M."xsd:string |
| http://purl.uniprot.org/citations/21810534 | http://purl.uniprot.org/core/author | "Moore T.C."xsd:string |
| http://purl.uniprot.org/citations/21810534 | http://purl.uniprot.org/core/author | "Petro T.M."xsd:string |
| http://purl.uniprot.org/citations/21810534 | http://purl.uniprot.org/core/author | "Al-Salleeh F.M."xsd:string |
| http://purl.uniprot.org/citations/21810534 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21810534 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/21810534 | http://purl.uniprot.org/core/pages | "40-48"xsd:string |
| http://purl.uniprot.org/citations/21810534 | http://purl.uniprot.org/core/title | "IRF3 polymorphisms induce different innate anti-Theiler's virus immune responses in RAW264.7 macrophages."xsd:string |
| http://purl.uniprot.org/citations/21810534 | http://purl.uniprot.org/core/volume | "418"xsd:string |
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