| http://purl.uniprot.org/citations/21813452 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21813452 | http://www.w3.org/2000/01/rdf-schema#comment | "Acquisition of homozygous activating growth factor receptor mutations might accelerate cancer progression through a simple gene-dosage effect. Internal tandem duplications (ITDs) of FLT3 occur in approximately 25% cases of acute myeloid leukemia and induce ligand-independent constitutive signaling. Homozygous FLT3-ITDs confer an adverse prognosis and are frequently detected at relapse. Using a mouse knockin model of Flt3-internal tandem duplication (Flt3-ITD)-induced myeloproliferation, we herein demonstrate that the enhanced myeloid phenotype and expansion of granulocyte-monocyte and primitive Lin(-)Sca1(+)c-Kit(+) progenitors in Flt3-ITD homozygous mice can in part be mediated through the loss of the second wild-type allele. Further, whereas autocrine FLT3 ligand production has been implicated in FLT3-ITD myeloid malignancies and resistance to FLT3 inhibitors, we demonstrate here that the mouse Flt3(ITD/ITD) myeloid phenotype is FLT3 ligand-independent."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-06-289207"xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Ma Z."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Mansour A."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Suda T."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Jacobsen S.E."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Masson K."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Ronnstrand L."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Arai F."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Atkinson D."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Nerlov C."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Mead A.J."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Ferry H."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Sitnicka E."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Buza-Vidas N."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Cammenga J."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Luc S."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Boiers C."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Kharazi S."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Hultquist A."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/author | "Reckzeh K."xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21813452 | http://purl.uniprot.org/core/pages | "3613-3621"xsd:string |