| http://purl.uniprot.org/citations/21813735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21813735 | http://www.w3.org/2000/01/rdf-schema#comment | "The TRAPP complexes are multimeric guanine exchange factors (GEFs) for the Rab GTPase Ypt1p. The three complexes (TRAPPI, TRAPPII, and TRAPPIII) share a core of common subunits required for GEF activity, as well as unique subunits (Trs130p, Trs120p, Trs85p, and Trs65p) that redirect the GEF from the endoplasmic reticulum-Golgi pathway to different cellular locations where TRAPP mediates distinct membrane trafficking events. Roles for three of the four unique TRAPP subunits have been described before; however, the role of the TRAPPII-specific subunit Trs65p has remained elusive. Here we demonstrate that Trs65p directly binds to the C-terminus of the Arf1p exchange factor Gea2p and provide in vivo evidence that this interaction is physiologically relevant. Gea2p and TRAPPII also bind to the yeast orthologue of the γ subunit of the COPI coat complex (Sec21p), a known Arf1p effector. These and previous findings reveal that TRAPPII is part of an Arf1p GEF-effector loop that appears to play a role in recruiting or stabilizing TRAPPII to membranes. In support of this proposal, we show that TRAPPII is more soluble in an arf1Δ mutant."xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e11-03-0197"xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/author | "Chen S."xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/author | "Cai H."xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/author | "Park S.K."xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/author | "Menon S."xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/author | "Jackson C.L."xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/author | "Ferro-Novick S."xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/pages | "3634-3644"xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/title | "Trs65p, a subunit of the Ypt1p GEF TRAPPII, interacts with the Arf1p exchange factor Gea2p to facilitate COPI-mediated vesicle traffic."xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/21813735 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21813735 |
| http://purl.uniprot.org/citations/21813735 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21813735 |
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