| http://purl.uniprot.org/citations/2181450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2181450 | http://www.w3.org/2000/01/rdf-schema#comment | "In yeast, the mRNA encoded by the MAT alpha 1 gene is unstable (t1/2 = 5 min) and the mRNAs encoded by the ACT1 gene (t1/2 = 30 min) and the PGK1 gene (t1/2 = 45 min) are stable. To understand the RNA structural features that dictate mRNA decay rates in yeast, we have constructed PGK1/MAT alpha 1 and ACT1/MAT alpha 1 gene fusions and analyzed the decay rates of the resultant chimeric transcripts. Fusion of a MAT alpha 1 segment containing 73% of the coding region and the 3' untranslated region to either of the stable genes is sufficient to cause rapid decay of the chimeric mRNAs (t1/2 = 6-7.5 min). Sequences required for this rapid decay are not found in the MAT alpha 1 3' untranslated region but are located within a 42-nucleotide segment of the coding region that has a high content (8 out of 14) of rare codons. Introduction of a translational stop codon upstream of this region stabilizes the hybrid mRNAs, indicating that the rapid decay promoted by these sequences is dependent on ribosomal translocation."xsd:string |
| http://purl.uniprot.org/citations/2181450 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.87.7.2780"xsd:string |
| http://purl.uniprot.org/citations/2181450 | http://purl.uniprot.org/core/author | "Jacobson A."xsd:string |
| http://purl.uniprot.org/citations/2181450 | http://purl.uniprot.org/core/author | "Parker R."xsd:string |
| http://purl.uniprot.org/citations/2181450 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2181450 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/2181450 | http://purl.uniprot.org/core/pages | "2780-2784"xsd:string |
| http://purl.uniprot.org/citations/2181450 | http://purl.uniprot.org/core/title | "Translation and a 42-nucleotide segment within the coding region of the mRNA encoded by the MAT alpha 1 gene are involved in promoting rapid mRNA decay in yeast."xsd:string |
| http://purl.uniprot.org/citations/2181450 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/2181450 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2181450 |
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| http://purl.uniprot.org/uniprot/P00560 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2181450 |
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| http://purl.uniprot.org/uniprot/P0CY07 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2181450 |