| http://purl.uniprot.org/citations/21814517 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21814517 | http://www.w3.org/2000/01/rdf-schema#comment | "Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10(-8)) in GWAS were further genotyped in an independent Japanese samples (818 cases and 1,032 controls) and in Korean samples (835 cases and 421 controls). SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40). HLA-DP allele analysis showed that DPA1*0201 and DPB1*0901, which were in strong linkage disequilibrium, were strongly associated with pediatric asthma (DPA1*0201: P = 5.5×10(-10), OR = 1.52, and DPB1*0901: P = 2.0×10(-7), OR = 1.49). Our findings show that genetic variants in the HLA-DP locus are associated with the risk of pediatric asthma in Asian populations."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002170"xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Akasawa A."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Kanno N."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Inoue K."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Goto Y."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Yoshida T."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Yoshihara S."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Sakamoto H."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Ochiai K."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Hirose H."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Saito I."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Kohno Y."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Sakamoto T."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Kang M.J."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Nomura I."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Hong S.J."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Arinami T."xsd:string |
| http://purl.uniprot.org/citations/21814517 | http://purl.uniprot.org/core/author | "Hirota T."xsd:string |