| http://purl.uniprot.org/citations/21816922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21816922 | http://www.w3.org/2000/01/rdf-schema#comment | "The miR-17~92 cluster is a potent microRNA-encoding oncogene. Here, we show that miR-17~92 synergizes with loss of Rb family members to promote retinoblastoma. We observed miR-17~92 genomic amplifications in murine retinoblastoma and high expression of miR-17~92 in human retinoblastoma. While miR-17~92 was dispensable for mouse retinal development, miR-17~92 overexpression, together with deletion of Rb and p107, led to rapid emergence of retinoblastoma with frequent metastasis to the brain. miR-17~92 oncogenic function in retinoblastoma was not mediated by a miR-19/PTEN axis toward apoptosis suppression, as found in lymphoma/leukemia models. Instead, miR-17~92 increased the proliferative capacity of Rb/p107-deficient retinal cells. We found that deletion of Rb family members led to compensatory up-regulation of the cyclin-dependent kinase inhibitor p21Cip1. miR-17~92 overexpression counteracted p21Cip1 up-regulation, promoted proliferation, and drove retinoblastoma formation. These results demonstrate that the oncogenic determinants of miR-17~92 are context-specific and provide new insights into miR-17~92 function as an RB-collaborating gene in cancer."xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.17027411"xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/author | "Thomson J.M."xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/author | "Mu D."xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/author | "Hammond S.M."xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/author | "Mukai S."xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/author | "MacPherson D."xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/author | "Conkrite K."xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/author | "Sundby M."xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/pages | "1734-1745"xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/title | "miR-17~92 cooperates with RB pathway mutations to promote retinoblastoma."xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/21816922 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21816922 |
| http://purl.uniprot.org/citations/21816922 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21816922 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GR06-mappedCitation-21816922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21816922 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRM0-mappedCitation-21816922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21816922 |
| http://purl.uniprot.org/uniprot/#_A2KBX4-mappedCitation-21816922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21816922 |
| http://purl.uniprot.org/uniprot/#_E9Q5C5-mappedCitation-21816922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21816922 |
| http://purl.uniprot.org/uniprot/#_Q64700-mappedCitation-21816922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21816922 |
| http://purl.uniprot.org/uniprot/#_Q64701-mappedCitation-21816922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21816922 |
| http://purl.uniprot.org/uniprot/#_P39689-mappedCitation-21816922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21816922 |
| http://purl.uniprot.org/uniprot/#_Q3V0V3-mappedCitation-21816922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21816922 |