| http://purl.uniprot.org/citations/21817065 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21817065 | http://www.w3.org/2000/01/rdf-schema#comment | "Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the immune response. Neutralization or genetic deletion of MIF does not completely abrogate activation responses, however, and deletion of the MIF receptor, CD74, produces a more pronounced phenotype than MIF deficiency. We hypothesized that these observations may be explained by a second MIF-like ligand, and we considered a probable candidate to be the protein encoded by the homologous, D-dopachrome tautomerase (D-DT) gene. We show that recombinant D-DT protein binds CD74 with high affinity, leading to activation of ERK1/2 MAP kinase and downstream proinflammatory pathways. Circulating D-DT levels correlate with disease severity in sepsis or malignancy, and the specific immunoneutralization of D-DT protects mice from lethal endotoxemia by reducing the expression of downstream effector cytokines. These data indicate that D-DT is a MIF-like cytokine with an overlapping spectrum of activities that are important for our understanding of MIF-dependent physiology and pathology."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1102941108"xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Fan J."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Xiong H."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Schulte W."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Du X."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Leng L."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Das R."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Chagnon F."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Lolis E."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Bernhagen J."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Bucala R."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Mor G."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Lue H."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Merk M."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Zierow S."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/author | "Lesur O."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/pages | "E577-85"xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/title | "The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)."xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/21817065 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21817065 |