| http://purl.uniprot.org/citations/21827952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21827952 | http://www.w3.org/2000/01/rdf-schema#comment | "The cyanobacterial Oscillatory Agardhii agglutinin (OAA) is a recently discovered HIV-inactivating lectin that interacts with high-mannose sugars. Nuclear magnetic resonance (NMR) binding studies between OAA and α3,α6-mannopentaose (Manα(1-3)[Manα(1-3)[Manα(1-6)]Manα(1-6)]Man), the branched core unit of Man-9, revealed two binding sites at opposite ends of the protein, exhibiting essentially identical affinities. Atomic details of the specific protein-sugar contacts in the recognition loops of OAA were delineated in the high-resolution crystal structures of free and glycan-complexed protein. No major changes in the overall protein structure are induced by carbohydrate binding, with essentially identical apo- and sugar-bound conformations in binding site 1. A single peptide bond flip at W77-G78 is seen in binding site 2. Our combined NMR and crystallographic results provide structural insights into the mechanism by which OAA specifically recognizes the branched Man-9 core, distinctly different from the recognition of the D1 and D3 arms at the nonreducing end of high-mannose carbohydrates by other antiviral lectins."xsd:string |
| http://purl.uniprot.org/citations/21827952 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2011.05.010"xsd:string |
| http://purl.uniprot.org/citations/21827952 | http://purl.uniprot.org/core/author | "Gronenborn A.M."xsd:string |
| http://purl.uniprot.org/citations/21827952 | http://purl.uniprot.org/core/author | "Koharudin L.M."xsd:string |
| http://purl.uniprot.org/citations/21827952 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21827952 | http://purl.uniprot.org/core/name | "Structure"xsd:string |
| http://purl.uniprot.org/citations/21827952 | http://purl.uniprot.org/core/pages | "1170-1181"xsd:string |
| http://purl.uniprot.org/citations/21827952 | http://purl.uniprot.org/core/title | "Structural basis of the anti-HIV activity of the cyanobacterial Oscillatoria Agardhii agglutinin."xsd:string |
| http://purl.uniprot.org/citations/21827952 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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| http://purl.uniprot.org/uniprot/P84330 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21827952 |
| http://purl.uniprot.org/uniprot/Q3KJ04 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21827952 |