| http://purl.uniprot.org/citations/21829390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21829390 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21829390 | http://www.w3.org/2000/01/rdf-schema#comment | "Seam cells in Caenorhabditis elegans provide a paradigm for the stem cell mode of division, with the ability to both self-renew and produce daughters that differentiate. The transcription factor RNT-1 and its DNA binding partner BRO-1 (homologues of the mammalian cancer-associated stem cell regulators RUNX and CBFβ, respectively) are known rate-limiting regulators of seam cell proliferation. Here, we show, using a combination of comparative genomics and DNA binding assays, that bro-1 expression is directly regulated by the GATA factor ELT-1. elt-1(RNAi) animals display similar seam cell lineage defects to bro-1 mutants, but have an additional phenotype in which seam cells lose their stem cell-like properties and differentiate inappropriately by fusing with the hyp7 epidermal syncytium. This phenotype is dependent on the fusogen EFF-1, which we show is repressed by ELT-1 in seam cells. Overall, our data suggest that ELT-1 has dual roles in the stem-like seam cells, acting both to promote proliferation and prevent differentiation."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002200"xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002200"xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/author | "Appleford P.J."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/author | "Appleford P.J."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/author | "Woollard A."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/author | "Woollard A."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/author | "Brabin C."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/author | "Brabin C."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/name | "PLoS Genet."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/pages | "E1002200"xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/pages | "E1002200"xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/title | "The Caenorhabditis elegans GATA factor ELT-1 works through the cell proliferation regulator BRO-1 and the Fusogen EFF-1 to maintain the seam stem-like fate."xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/21829390 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21829390 |
| http://purl.uniprot.org/citations/21829390 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21829390 |
| http://purl.uniprot.org/citations/21829390 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21829390 |
| http://purl.uniprot.org/citations/21829390 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21829390 |