| http://purl.uniprot.org/citations/2183031 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2183031 | http://www.w3.org/2000/01/rdf-schema#comment | "The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells. Mutations of the NF-kappa B site abolished complex formation with both purified NF-kappa B and the nuclear extract protein. Transient expression of chloramphenicol acetyltransferase (CAT) plasmids containing the IL-6 promoter revealed very little activity of the promoter in U-937 monocytic cells and in HeLa cells before stimulation. However, stimulation of U-937 and HeLa cells by inducers of NF-kappa B led to a dramatic increase in CAT activity. Mutations in the NF-kappa B-binding site abolished inducibility of IL-6 promoter-cat constructs in U-937 cells by lipopolysaccharide, tumor necrosis factor alpha, the double-stranded RNA poly(IC), or phytohemagglutinin and in HeLa cells by tumor necrosis factor alpha and drastically reduced but did not completely eliminate inducibility in HeLa cells stimulated by double-stranded RNA poly(IC) or phorbol 12-myristate 13-acetate. These results suggest that NF-kappa B is an important mediator for activation of the IL-6 gene by a variety of IL-6 inducers in both U-937 and HeLa cells and that alternative inducible enhancer elements contribute in a cell-specific manner to IL-6 gene induction. Because NF-kappa B is involved in the control of a variety of genes activated upon inflammation, NF-kappa B may play a central role in the inflammatory response to infection and tissue injury."xsd:string |
| http://purl.uniprot.org/citations/2183031 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.10.5.2327-2334.1990"xsd:string |
| http://purl.uniprot.org/citations/2183031 | http://purl.uniprot.org/core/author | "Baltimore D."xsd:string |
| http://purl.uniprot.org/citations/2183031 | http://purl.uniprot.org/core/author | "Libermann T.A."xsd:string |
| http://purl.uniprot.org/citations/2183031 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2183031 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/2183031 | http://purl.uniprot.org/core/pages | "2327-2334"xsd:string |
| http://purl.uniprot.org/citations/2183031 | http://purl.uniprot.org/core/title | "Activation of interleukin-6 gene expression through the NF-kappa B transcription factor."xsd:string |
| http://purl.uniprot.org/citations/2183031 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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