| http://purl.uniprot.org/citations/21831887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21831887 | http://www.w3.org/2000/01/rdf-schema#comment | "Peripheral myelin protein 22 (PMP22) and protein 0 (P0) are major peripheral myelin glycoproteins, and mutations in these two proteins are associated with hereditary demyelinating peripheral neuropathies. Calnexin, calreticulin, and ERp57 are critical components of protein quality control responsible for proper folding of newly synthesized glycoproteins. Here, using confocal microscopy, we show that cell surface targeting of P0 and PMP22 is not affected in the absence of the endoplasmic reticulum chaperones. However, the folding and function (adhesiveness) of PMP22 and P0, measured using the adhesion assay, are affected significantly in the absence of calnexin but not in the absence of calreticulin. Deficiency in oxidoreductase ERp57 results in impaired folding and function of P0, a disulfide bond-containing protein, but does not have any effect on folding or function of PMP22 (a protein that does not contain a disulfide bond). We concluded that calnexin and ERp57, but not calreticulin, play an important role in the biology of peripheral myelin proteins PMP22 and P0, and, consequently, these chaperones may contribute to the pathogenesis of peripheral neuropathies and the diversity of these neurological disorders."xsd:string |
| http://purl.uniprot.org/citations/21831887 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.11-184911"xsd:string |
| http://purl.uniprot.org/citations/21831887 | http://purl.uniprot.org/core/author | "Jung J."xsd:string |
| http://purl.uniprot.org/citations/21831887 | http://purl.uniprot.org/core/author | "Michalak M."xsd:string |
| http://purl.uniprot.org/citations/21831887 | http://purl.uniprot.org/core/author | "Coe H."xsd:string |
| http://purl.uniprot.org/citations/21831887 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21831887 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/21831887 | http://purl.uniprot.org/core/pages | "3929-3937"xsd:string |
| http://purl.uniprot.org/citations/21831887 | http://purl.uniprot.org/core/title | "Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22."xsd:string |
| http://purl.uniprot.org/citations/21831887 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/21831887 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21831887 |
| http://purl.uniprot.org/citations/21831887 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21831887 |
| http://purl.uniprot.org/uniprot/#_P35564-mappedCitation-21831887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21831887 |
| http://purl.uniprot.org/uniprot/#_F6Q404-mappedCitation-21831887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21831887 |
| http://purl.uniprot.org/uniprot/#_Q3TXE5-mappedCitation-21831887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21831887 |
| http://purl.uniprot.org/uniprot/#_P27773-mappedCitation-21831887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21831887 |
| http://purl.uniprot.org/uniprot/#_Q5SUC3-mappedCitation-21831887 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21831887 |
| http://purl.uniprot.org/uniprot/P27773 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21831887 |
| http://purl.uniprot.org/uniprot/Q3TXE5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21831887 |
| http://purl.uniprot.org/uniprot/F6Q404 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21831887 |
| http://purl.uniprot.org/uniprot/P35564 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21831887 |
| http://purl.uniprot.org/uniprot/Q5SUC3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21831887 |