| http://purl.uniprot.org/citations/21833019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21833019 | http://www.w3.org/2000/01/rdf-schema#comment | "Vitiligo is a depigmenting disorder of the skin that is characterized by the loss of functional melanocytes from the lesional sites. Although the exact etiology is not understood, autoimmunity is thought to be a crucial deterministic factor. A recurring theme of several autoimmune disorders is the aberrant presentation of self-antigens to the immune system, which triggers downstream perturbations. Here we examine the role of alleles of HLA class I and class II loci to delineate vitiligo manifestation in two distinct populations. Our studies have identified three specific alleles, HLA-A*33:01, HLA-B*44:03, and HLA-DRB1*07:01, to be significantly increased in vitiligo patients as compared with controls in both the initial study on North Indians (N=1,404) and the replication study in Gujarat (N=355) cases, establishing their positive association with vitiligo. Both generalized and localized vitiligo have the same predisposing major histocompatibility complex alleles, i.e., B*44:03 and DRB1*07:01, in both the populations studied, beside the differences in the frequencies of other alleles, suggesting that localized vitiligo too may be an autoimmune disorder. Significant differences in the amino-acid signatures of the peptide-binding pockets of HLA-A and HLA-B α-chain and HLA-DR β-chain were observed between vitiligo patients and unaffected controls."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2011.240"xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Singh A."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Gupta S."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Gokhale R.S."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Sharma P."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Sharma V.K."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Dwivedi M."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Rani R."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Begum R."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Laddha N.C."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Kar H.K."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/author | "Tembhre M.K."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/pages | "124-134"xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/title | "HLA alleles and amino-acid signatures of the peptide-binding pockets of HLA molecules in vitiligo."xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21833019 |
| http://purl.uniprot.org/citations/21833019 | http://purl.uniprot.org/core/group | "Indian Genome Variation Consortium"xsd:string |
| http://purl.uniprot.org/citations/21833019 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21833019 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-21833019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21833019 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-21833019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21833019 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-21833019 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21833019 |