| http://purl.uniprot.org/citations/21835646 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21835646 | http://www.w3.org/2000/01/rdf-schema#comment | "The transport of calcium ions (Ca(2+)) to the cytosol is essential for immunoreceptor signaling, regulating lymphocyte differentiation, activation, and effector function. Increases in cytosolic-free Ca(2+) concentrations are thought to be mediated through two interconnected and complementary mechanisms: the release of endoplasmic reticulum Ca(2+) "stores" and "store-operated" Ca(2+) entry via plasma membrane channels. However, the identity of molecular components conducting Ca(2+) currents within developing and mature T cells is unclear. Here, we have demonstrated that the L-type "voltage-dependent" Ca(2+) channel Ca(V)1.4 plays a cell-intrinsic role in the function, development, and survival of naive T cells. Plasma membrane Ca(V)1.4 was found to be essential for modulation of intracellular Ca(2+) stores and T cell receptor (TCR)-induced rises in cytosolic-free Ca(2+), impacting activation of Ras-extracellular signal-regulated kinase (ERK) and nuclear factor of activated T cells (NFAT) pathways. Collectively, these studies revealed that Ca(V)1.4 functions in controlling naive T cell homeostasis and antigen-driven T cell immune responses."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2011.07.011"xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Gopaul R."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Jefferies W.A."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Tan R."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Wang Y.T."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Fedida D."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Bech-Hansen N.T."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Priatel J.J."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Teh H.S."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Choi K.B."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Hunt S.V."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "McIntyre-Smith A."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Omilusik K."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/author | "Waterfield D."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/pages | "349-360"xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/title | "The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis."xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/21835646 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21835646 |
| http://purl.uniprot.org/citations/21835646 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21835646 |