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http://purl.uniprot.org/citations/21835711http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21835711http://www.w3.org/2000/01/rdf-schema#comment"

Objectives

To compare [NT-proBNP], [NT-proANP] and [cTnI] between control dogs with respiratory disease without pulmonary hypertension (PH) and dogs with pre-capillary PH, and to assess the accuracy of [NT-proBNP], [NT-proANP], [cTnI] to predict Doppler-derived peak tricuspid regurgitation (TR) gradient.

Animals

20 dogs. 8 control dogs with respiratory disease with no PH and 12 with pre-capillary PH.

Methods

[NT-proBNP], [NT-proANP] and [cTnI] were compared between the 2 groups and simple linear regression analysis was used to predict peak TR gradients from various blood biomarkers.

Results

Median [NT-proBNP] was higher in the dogs with PH (2011 pmol/L, 274-7713 pmol/L) compared to control dogs (744 pmol/L; 531-2710 pmol/L) (p = 0.0339). [NT-proBNP] was associated with peak TR gradient (R(2) = 0.7851, p = 0.0001). Median [NT-proANP] did not differ between dogs with PH (1747 fmol/L; 894-2884 fmol/L) and control dogs (1209 fmol/L; 976-1389 fmol/L (p = 0.058). [NT-proANP] was not associated with peak TR gradient (R(2) = 0.2780, p = 0.0781). Median [cTnI] did not differ between dogs with PH (0.2850 ng/mL; 0.19-1.13 ng/mL) and control dogs (0.2 ng/mL; 0.19-0.82 ng/mL, p = 0.3051). Median [TnI] was not associated with peak TR gradient (R(2) = 0.024, p = 0.6307).

Conclusions

[NT-proBNP] concentration is significantly higher in dogs with pre-capillary PH when compared to dogs with respiratory disease without PH, and [NT-proBNP] may be useful to predict the severity of estimated PH. Elevations in [NT-proBNP] due to pre-capillary PH may complicate the interpretation of [NT-proBNP] elevations in patients presenting with cardiorespiratory abnormalities. [NT-proANP] and [cTnI] were not elevated in dogs with pre-capillary PH."xsd:string
http://purl.uniprot.org/citations/21835711http://purl.org/dc/terms/identifier"doi:10.1016/j.jvc.2011.04.003"xsd:string
http://purl.uniprot.org/citations/21835711http://purl.uniprot.org/core/author"Kellihan H.B."xsd:string
http://purl.uniprot.org/citations/21835711http://purl.uniprot.org/core/author"Mackie B.A."xsd:string
http://purl.uniprot.org/citations/21835711http://purl.uniprot.org/core/author"Stepien R.L."xsd:string
http://purl.uniprot.org/citations/21835711http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21835711http://purl.uniprot.org/core/name"J Vet Cardiol"xsd:string
http://purl.uniprot.org/citations/21835711http://purl.uniprot.org/core/pages"171-182"xsd:string
http://purl.uniprot.org/citations/21835711http://purl.uniprot.org/core/title"NT-proBNP, NT-proANP and cTnI concentrations in dogs with pre-capillary pulmonary hypertension."xsd:string
http://purl.uniprot.org/citations/21835711http://purl.uniprot.org/core/volume"13"xsd:string
http://purl.uniprot.org/citations/21835711http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21835711
http://purl.uniprot.org/citations/21835711http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21835711
http://purl.uniprot.org/uniprot/#_P07499-mappedCitation-21835711http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21835711
http://purl.uniprot.org/uniprot/P07499http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21835711