| http://purl.uniprot.org/citations/21835787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21835787 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21835787 | http://www.w3.org/2000/01/rdf-schema#comment | "Successful intracellular pathogens must evade or neutralize the innate immune defenses of their host cells and render the cellular environment permissive for replication. For example, to replicate efficiently in CD4(+) T lymphocytes, human immunodeficiency virus type 1 (HIV-1) encodes a protein called viral infectivity factor (Vif) that promotes pathogenesis by triggering the degradation of the retrovirus restriction factor APOBEC3G. Other APOBEC3 proteins have been implicated in HIV-1 restriction, but the relevant repertoire remains ambiguous. Here we present the first comprehensive analysis of the complete, seven-member human and rhesus APOBEC3 families in HIV-1 restriction. In addition to APOBEC3G, we find that three other human APOBEC3 proteins, APOBEC3D, APOBEC3F, and APOBEC3H, are all potent HIV-1 restriction factors. These four proteins are expressed in CD4(+) T lymphocytes, are packaged into and restrict Vif-deficient HIV-1 when stably expressed in T cells, mutate proviral DNA, and are counteracted by HIV-1 Vif. Furthermore, APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H of the rhesus macaque also are packaged into and restrict Vif-deficient HIV-1 when stably expressed in T cells, and they are all neutralized by the simian immunodeficiency virus Vif protein. On the other hand, neither human nor rhesus APOBEC3A, APOBEC3B, nor APOBEC3C had a significant impact on HIV-1 replication. These data strongly implicate a combination of four APOBEC3 proteins--APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H--in HIV-1 restriction."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.05238-11"xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.05238-11"xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.org/dc/terms/identifier | "doi:10.1128/JVI.05238-11"xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Brown W.L."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Brown W.L."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Harris R.S."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Harris R.S."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Hultquist J.F."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Hultquist J.F."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "LaRue R.S."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "LaRue R.S."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Lackey L."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Lackey L."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Lengyel J.A."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Lengyel J.A."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Refsland E.W."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "Refsland E.W."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/author | "LRrue R.S."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/21835787 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |