| http://purl.uniprot.org/citations/21835891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21835891 | http://www.w3.org/2000/01/rdf-schema#comment | "c-myc oncogene is implicated in tumorigenesis of many cancers, including breast cancer. Although c-myc is a well-known estrogen-induced gene, its promoter has no estrogen-response element, and the underlying mechanism by which estrogen induces its expression remains obscure. Recent genome-wide studies by us and others suggested that distant elements may mediate estrogen induction of gene expression. In this study, we investigated the molecular mechanism by which estrogen induces c-myc expression with a focus on these distal elements. Estrogen rapidly induced c-myc expression in estrogen receptor (ER)-positive breast cancer cells. Although estrogen had little effect on c-myc proximal promoter activity, it did stimulate the activity of a luciferase reporter containing a distal 67-kb enhancer. Estrogen induction of this luciferase reporter was dependent upon both a half-estrogen response element and an activator protein 1 (AP-1) site within this enhancer, which are conserved across 11 different mammalian species. Small interfering RNA experiments and chromatin immunoprecipitation assays demonstrated the necessity of ER and AP-1 cross talk for estrogen to induce c-myc expression. TAM67, the AP-1 dominant negative, partially inhibited estrogen induction of c-myc expression and suppressed estrogen-induced cell cycle progression. Together, these results demonstrate a novel pathway of estrogen regulation of gene expression by cooperation between ER and AP-1 at the distal enhancer element and that AP-1 is involved in estrogen induction of the c-myc oncogene. These results solve the long-standing question in the field of endocrinology of how estrogen induces c-myc expression."xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.org/dc/terms/identifier | "doi:10.1210/me.2011-1037"xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/author | "Brown M."xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/author | "Kim H."xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/author | "Brown P.H."xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/author | "Mazumdar A."xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/author | "Mayer J.A."xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/author | "Fertuck K."xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/name | "Mol Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/pages | "1527-1538"xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/title | "Estrogen induces c-myc gene expression via an upstream enhancer activated by the estrogen receptor and the AP-1 transcription factor."xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/21835891 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21835891 |
| http://purl.uniprot.org/citations/21835891 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21835891 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-21835891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835891 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW1-mappedCitation-21835891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835891 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-21835891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835891 |
| http://purl.uniprot.org/uniprot/#_P0C5Y9-mappedCitation-21835891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835891 |
| http://purl.uniprot.org/uniprot/#_P57053-mappedCitation-21835891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835891 |
| http://purl.uniprot.org/uniprot/#_Q14268-mappedCitation-21835891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835891 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV8-mappedCitation-21835891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835891 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV9-mappedCitation-21835891 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835891 |