| http://purl.uniprot.org/citations/21835954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21835954 | http://www.w3.org/2000/01/rdf-schema#comment | "The ability of IFN-γ to enhance graft-versus-leukemia (GVL) activity without direct interaction with leukemia cells was examined by comparing GVL effects against IFN-γ receptor-deficient (GRKO) leukemia between wild-type (WT) and IFN-γ-deficient (GKO) allogeneic hematopoietic cell transplantation (allo-HCT). We established a primary IFN-γ-unresponsive T-cell leukemia model using virally-transduced GRKO B6 mouse bone marrow cells overexpressing Notch1. We first assessed GVL effects in lethally-irradiated B6 mice receiving CD4-depleted allo-HCT from WT or GKO BALB/c donors. Administration of CD4(+) cell-depleted allo-HCT from WT, but not GKO, BALB/c donors mediated significant GVL effects against GRKO leukemia. Similar results were obtained in pre-established allogeneic chimeras receiving delayed donor lymphocyte infusion (DLI). Although both WT and GKO DLI achieved significant anti-tumor responses, the former was markedly stronger than the latter. These data indicate that IFN-γ is capable of promoting GVL effects via mechanisms independent of its interaction with leukemia cells."xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-05-283887"xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/author | "Wang G."xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/author | "Yu H."xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/author | "Cheng T."xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/author | "Yang Y.G."xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/author | "Liang T."xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/author | "Yeap B.Y."xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/pages | "3721-3724"xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/title | "IFN-gamma promotes graft-versus-leukemia effects without directly interacting with leukemia cells in mice after allogeneic hematopoietic cell transplantation."xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://purl.uniprot.org/core/volume | "118"xsd:string |
| http://purl.uniprot.org/citations/21835954 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21835954 |
| http://purl.uniprot.org/citations/21835954 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21835954 |
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| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-21835954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835954 |
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| http://purl.uniprot.org/uniprot/#_C4NUL9-mappedCitation-21835954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835954 |
| http://purl.uniprot.org/uniprot/#_C4NUM1-mappedCitation-21835954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835954 |
| http://purl.uniprot.org/uniprot/#_Q540M5-mappedCitation-21835954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21835954 |