| http://purl.uniprot.org/citations/21838611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21838611 | http://www.w3.org/2000/01/rdf-schema#comment | "TTF-1 and napsin A are useful biomarkers for differentiating primary lung adenocarcinoma from metastatic tumors. Studies have shown, however, that TTF-1 and napsin A also can be expressed in extrapulmonary carcinomas, and that a small fraction of primary lung adenocarcinomas do not co-express these two markers. We attempted to determine whether a tissue-specific transcriptional factor, PAX8, can help determine primary sites of lung carcinomas. Immunohistochemical stains for PAX8, TTF-1 and napsin A were performed on 103 cases of metastatic lung carcinomas from a variety of origins and 120 cases of primary lung adenocarcinomas. Our data demonstrated that all 103 metastatic carcinomas were negative for napsin A, while 14 (13.6%; four thyroid, two endometrium, three colon, one prostate, one salivary adenoid cystic, two renal cell carcinomas, and one ovary) showed weak to strong TTF-1 nuclear staining in 5-60% of the tumor cells. All primary lung adenocarcinomas were negative for PAX8, whereas 46 (44.7%) metastatic carcinomas from the kidney (29/33), ovary (6/8), endometrium (5/5), endocervix (1/1), thyroid (4/5) and urinary tract (1/3) were positive for PAX8. Our data demonstrate that of combined use of PAX8, TTF-1 and napsin A is reliable to separate reliably lung primary from metastatic tumors."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.org/dc/terms/identifier | "doi:10.3109/10520295.2011.591838"xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/author | "Fan L."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/author | "Ye J."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/author | "Wang H.L."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/author | "McMahon L.A."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/author | "Hameed O."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/author | "Findeis-Hosey J.J."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/name | "Biotech Histochem"xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/pages | "30-34"xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/title | "Diagnostic utility of PAX8, TTF-1 and napsin A for discriminating metastatic carcinoma from primary adenocarcinoma of the lung."xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/21838611 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21838611 |
| http://purl.uniprot.org/citations/21838611 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21838611 |
| http://purl.uniprot.org/uniprot/#_Q13306-mappedCitation-21838611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21838611 |
| http://purl.uniprot.org/uniprot/#_P43699-mappedCitation-21838611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21838611 |
| http://purl.uniprot.org/uniprot/#_M0QXC5-mappedCitation-21838611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21838611 |
| http://purl.uniprot.org/uniprot/#_O14956-mappedCitation-21838611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21838611 |
| http://purl.uniprot.org/uniprot/#_O96009-mappedCitation-21838611 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21838611 |
| http://purl.uniprot.org/uniprot/M0QXC5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21838611 |