| http://purl.uniprot.org/citations/21839130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21839130 | http://www.w3.org/2000/01/rdf-schema#comment | "Adrenomedullin (AM) is highly expressed in various cancer cell lines, suggesting a possible association with cancer growth. In the present study, we examined the expression and/or concentration of AM, its related peptide, adrenomedullin2/intermedin (AM2/IMD) and their receptors in human colorectal cancer and the surrounding normal tissue. In addition, we assessed the correlation between the expression of AM and AM2/IMD with that of vascular endothelial growth factor (VEGF)-A and matrix metalloproteinase (MMP)-9. Using a specific immunoradiometric assay, we found that AM concentrations were 2-11-fold higher in colorectal cancer tissues than in the surrounding normal tissues. Moreover, real-time quantitative RT-PCR showed that the expression levels of preproAM (+548%), preproAM2/IMD (+2674%), calcitonin receptor-like receptor (CLR) (+518%), receptor activity modifying protein (RAMP)2 (+281%), RAMP3 (+178%), VEGF-A (+277%) and MMP-9 (+864%) mRNAs were significantly higher in cancer tissues than in the surrounding normal tissues, and there was a positive correlation between the gene expressions of MMP-9 and preproAM (r=0.352; p=0.005), but not with preproAM2/IMD (r=0.041, p=0.406). Both AM and AM2/IMD immunoreactivity were detected mainly within cancer cells, whereas MMP-9 immunoreactivity was mostly seen in the surrounding stroma. These findings suggest that AM produced in colorectal tumors acts in concert with MMP-9 in the stroma to contribute to the pathogenesis of colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2011.07.012"xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/author | "Tsuchiya K."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/author | "Kitamura K."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/author | "Hoshiko S."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/author | "Nagata S."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/author | "Kuwasako K."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/author | "Hikosaka T."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/author | "Chijiiwa K."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/author | "Tsuruda T."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/author | "Inatsu H."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/pages | "1825-1831"xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/title | "Adrenomedullin production is increased in colorectal adenocarcinomas; its relation to matrix metalloproteinase-9."xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/21839130 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21839130 |
| http://purl.uniprot.org/citations/21839130 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21839130 |
| http://purl.uniprot.org/uniprot/#_B7Z7V0-mappedCitation-21839130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21839130 |
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| http://purl.uniprot.org/uniprot/#_B7Z747-mappedCitation-21839130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21839130 |
| http://purl.uniprot.org/uniprot/#_B7Z8A9-mappedCitation-21839130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21839130 |
| http://purl.uniprot.org/uniprot/#_F2YBS6-mappedCitation-21839130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21839130 |
| http://purl.uniprot.org/uniprot/#_Q9Y354-mappedCitation-21839130 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21839130 |