| http://purl.uniprot.org/citations/21839727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21839727 | http://www.w3.org/2000/01/rdf-schema#comment | "The inhibitors of apoptosis proteins (IAP), which include cIAP1, cIAP2 and XIAP, suppress apoptosis through the inhibition of caspases, and the activity of IAPs is regulated by a variety of IAP-binding proteins. Herein, we report the identification of a Vestigial-like 4 (Vgl-4), which functions as a transcription cofactor in cardiac myocytes, as a new IAP binding protein. Vgl-4 is expressed predominantly in the nucleus and its overexpression triggers a relocalization of IAPs from the cytoplasm to the nucleus. cIAP1/2-interacting protein TRAF2 (TNF receptor-associated factor 2) prevented the Vgl-4-driven nuclear localization of cIAP2. Accordingly, the forced relocation of IAPs to the nucleus by Vgl-4 significantly reduced their ability to prevent Bax- and TNFα-induced apoptosis, which can be recovered by co-expression with TRAF2. Our results suggest that Vgl-4 may play a role in the apoptotic pathways by regulating translocation of IAPs between different cell compartments."xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.07.117"xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/author | "Shin J.H."xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/author | "Park H.S."xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/author | "Lee T.H."xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/author | "Jun S.H."xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/author | "Lee C.J."xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/author | "Jin H.S."xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/pages | "454-459"xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/title | "A novel inhibitor of apoptosis protein (IAP)-interacting protein, Vestigial-like (Vgl)-4, counteracts apoptosis-inhibitory function of IAPs by nuclear sequestration."xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://purl.uniprot.org/core/volume | "412"xsd:string |
| http://purl.uniprot.org/citations/21839727 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21839727 |
| http://purl.uniprot.org/citations/21839727 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21839727 |
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| http://purl.uniprot.org/uniprot/#_A0A075B6E4-mappedCitation-21839727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21839727 |
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| http://purl.uniprot.org/uniprot/#_G5E9M7-mappedCitation-21839727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21839727 |
| http://purl.uniprot.org/uniprot/#_G5E9M9-mappedCitation-21839727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21839727 |
| http://purl.uniprot.org/uniprot/#_Q0H0I4-mappedCitation-21839727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21839727 |
| http://purl.uniprot.org/uniprot/#_Q0H0I7-mappedCitation-21839727 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21839727 |
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