| http://purl.uniprot.org/citations/21840486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21840486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21840486 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor hypoxia is associated with disease progression and treatment failure, but the hypoxia signaling mechanism is not fully understood. Here, we show that KLHL20, a Cullin3 (Cul3) substrate adaptor induced by HIF-1, coordinates with the actions of CDK1/2 and Pin1 to mediate hypoxia-induced PML proteasomal degradation. Furthermore, this PML destruction pathway participates in a feedback mechanism to maximize HIF-1α induction, thereby potentiating multiple tumor hypoxia responses, including metabolic reprogramming, epithelial-mesenchymal transition, migration, tumor growth, angiogenesis, and chemoresistance. In human prostate cancer, overexpression of HIF-1α, KLHL20, and Pin1 correlates with PML down-regulation, and hyperactivation of the PML destruction pathway is associated with disease progression. Our study indicates that the KLHL20-mediated PML degradation and HIF-1α autoregulation play key roles in tumor progression."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2011.07.008"xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2011.07.008"xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Chen H.Y."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Chen H.Y."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Tsai C.H."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Tsai C.H."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Lin Y.M."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Lin Y.M."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Shih H.M."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Shih H.M."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Lu K.P."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Lu K.P."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Chen T.Y."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Chen T.Y."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Lee Y.R."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Lee Y.R."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Chiang C.T."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Chiang C.T."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Chen R.H."xsd:string |
| http://purl.uniprot.org/citations/21840486 | http://purl.uniprot.org/core/author | "Chen R.H."xsd:string |