| http://purl.uniprot.org/citations/21840865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21840865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21840865 | http://www.w3.org/2000/01/rdf-schema#comment | "Four different SYP proteins (SYP-1, SYP-2, SYP-3, and SYP-4) have been proposed to form the central region of the synaptonemal complex (SC) thereby bridging the axes of paired meiotic chromosomes in Caenorhabditis elegans. Their interdependent localization suggests that they may interact within the SC. Our studies reveal for the first time how these SYP proteins are organized in the central region of the SC. Yeast two-hybrid and co-immunoprecipitation studies show that SYP-1 is the only SYP protein that is capable of homotypic interactions, and is able to interact with both SYP-2 and SYP-3 directly, whereas SYP-2 and SYP-3 do not seem to interact with each other. Specifically, the coiled-coil domain of SYP-1 is required both for its homotypic interactions and its interaction with the C-terminal domain of SYP-2. Meanwhile, SYP-3 interacts with the C-terminal end of SYP-1 via its N-terminal domain. Immunoelectron microscopy analysis provides insight into the orientation of these proteins within the SC. While the C-terminal domain of SYP-3 localizes in close proximity to the chromosome axes, the N-terminal domains of both SYP-1 and SYP-4, as well as the C-terminal domain of SYP-2, are located in the middle of the SC. Taking into account the different sizes of these proteins, their interaction abilities, and their orientation within the SC, we propose a model of how the SYP proteins link the homologous axes to provide the conserved structure and width of the SC in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.111.132431"xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.111.132431"xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Gu Y."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Vidal M."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Vidal M."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Hill D.E."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Hill D.E."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Saito T.T."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Saito T.T."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Colaiacovo M.P."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Colaiacovo M.P."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Smolikov S."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Smolikov S."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "McDonald K."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "McDonald K."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Hincapie M."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Hincapie M."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Schild-Pruefert K."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/author | "Schild-Pruefert K."xsd:string |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21840865 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |