| http://purl.uniprot.org/citations/21840999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21840999 | http://www.w3.org/2000/01/rdf-schema#comment | "4E-BP1 is a protein that, in its hypophosphorylated state, binds the mRNA cap-binding protein eIF4E and represses cap-dependent mRNA translation. By doing so, it plays a major role in the regulation of gene expression by controlling the overall rate of mRNA translation as well as the selection of mRNAs for translation. Phosphorylation of 4E-BP1 causes it to release eIF4E to function in mRNA translation. 4E-BP1 is also subject to covalent addition of N-acetylglucosamine to Ser or Thr residues (O-GlcNAcylation) as well as to truncation. In the truncated form, it is both resistant to phosphorylation and able to bind eIF4E with high affinity. In the present study, Ins2(Akita/+) diabetic mice were used to test the hypothesis that hyperglycemia and elevated flux of glucose through the hexosamine biosynthetic pathway lead to increased O-GlcNAcylation and truncation of 4E-BP1 and consequently decreased eIF4E function in the liver. The amounts of both full-length and truncated 4E-BP1 bound to eIF4E were significantly elevated in the liver of diabetic as compared with non-diabetic mice. In addition, O-GlcNAcylation of both the full-length and truncated proteins was elevated by 2.5- and 5-fold, respectively. Phlorizin treatment of diabetic mice lowered blood glucose concentrations and reduced the expression and O-GlcNAcylation of 4E-BP1. Additionally, when livers were perfused in the absence of insulin, 4E-BP1 phosphorylation in the livers of diabetic mice was normalized to the control value, yet O-GlcNAcylation and the association of 4E-BP1 with eIF4E remained elevated in the liver of diabetic mice. These findings provide insight into the pathogenesis of metabolic abnormalities associated with diabetes."xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.259457"xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://purl.uniprot.org/core/author | "Dennis M.D."xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://purl.uniprot.org/core/author | "Jefferson L.S."xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://purl.uniprot.org/core/author | "Kimball S.R."xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://purl.uniprot.org/core/author | "Bronson S.K."xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://purl.uniprot.org/core/author | "Schrufer T.L."xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21840999 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://purl.uniprot.org/core/pages | "34286-34297"xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://purl.uniprot.org/core/title | "Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes."xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21840999 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21840999 |
| http://purl.uniprot.org/citations/21840999 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21840999 |
| http://purl.uniprot.org/uniprot/#_D3YWU5-mappedCitation-21840999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21840999 |
| http://purl.uniprot.org/uniprot/#_D3Z595-mappedCitation-21840999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21840999 |
| http://purl.uniprot.org/uniprot/#_D3Z596-mappedCitation-21840999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21840999 |
| http://purl.uniprot.org/uniprot/#_E0CXX7-mappedCitation-21840999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21840999 |
| http://purl.uniprot.org/uniprot/#_D0EY27-mappedCitation-21840999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21840999 |
| http://purl.uniprot.org/uniprot/#_Q5EEX1-mappedCitation-21840999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21840999 |
| http://purl.uniprot.org/uniprot/#_P01326-mappedCitation-21840999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21840999 |
| http://purl.uniprot.org/uniprot/#_Q3TII9-mappedCitation-21840999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21840999 |
| http://purl.uniprot.org/uniprot/#_Q60876-mappedCitation-21840999 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21840999 |
| http://purl.uniprot.org/uniprot/D0EY27 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21840999 |