| http://purl.uniprot.org/citations/21844388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21844388 | http://www.w3.org/2000/01/rdf-schema#comment | "Innate CD8 T cells are found in mutant mouse models, but whether they are produced in a normal thymus remains controversial. Using the RAG2p-GFP mouse model, we found that ∼10% of TCRαβ(+) CD4(-)CD8(+) thymocytes were innate polyclonal T cells (GFP(+)CD44(hi)). Relative to conventional T cells, innate CD8 thymocytes displayed increased cell surface amounts of B7-H1, CD2, CD5, CD38, IL-2Rβ, and IL-4Rα and downmodulation of TCRβ. Moreover, they overexpressed several transcripts, including T-bet, Id3, Klf2, and, most of all, Eomes. Innate CD8 thymocytes were positively selected, mainly by nonhematopoietic MHCIa(+) cells. They rapidly produced high levels of IFN-γ upon stimulation and readily proliferated in response to IL-2 and IL-4. Furthermore, low numbers of innate CD8 thymocytes were sufficient to help conventional CD8 T cells expand and secrete cytokine following Ag recognition. This helper effect depended on CD44-mediated interactions between innate and conventional CD8 T cells. We concluded that innate TCRαβ(+) CD8 T cells represent a sizeable proportion of normal thymocytes whose development and function differ in many ways from those of conventional CD8 T cells."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1101097"xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/author | "Williams P."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/author | "Galipeau J."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/author | "Perreault C."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/author | "Hardy M.P."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/author | "Labrecque N."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/author | "Dulude G."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/author | "Rafei M."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/author | "Forner K.A."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/author | "Vanegas J.R."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/pages | "3133-3144"xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/title | "Development and function of innate polyclonal TCRalphabeta+ CD8+ thymocytes."xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/21844388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21844388 |
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| http://purl.uniprot.org/uniprot/#_A0A482D1Q0-mappedCitation-21844388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21844388 |
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