| http://purl.uniprot.org/citations/21844396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21844396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21844396 | http://www.w3.org/2000/01/rdf-schema#comment | "EBV-induced gene 2 (EBI2) was recently shown to direct the delayed movement of activated B cells to interfollicular and outer follicular regions of secondary lymphoid organs and to be required for mounting a normal T-dependent Ab response. In this study, we show that EBI2 promotes an early wave of Ag-activated B cell migration to the outer follicle in mice. Later, when B cells have moved to the T zone in a CCR7-dependent manner, EBI2 helps distribute the cells along the B zone-T zone boundary. Subsequent EBI2-dependent movement to the outer follicle coincides with CCR7 downregulation and is promoted by CD40 engagement. Using a bioassay, we identify a proteinase K-resistant, hydrophobic EBI2 ligand activity in lymphoid and nonlymphoid tissues. Production of EBI2 ligand activity by a cell line is sensitive to statins, suggesting production in a 3-hydroxy-3-methyl-glutaryl-CoA reductase-dependent manner. CD40-activated B cells show sustained EBI2-dependent responsiveness to the bioactivity. These findings establish a role for EBI2 in helping control B cell position at multiple stages during the Ab response and they suggest that EBI2 responds to a broadly distributed lipid ligand."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1101262"xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1101262"xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/author | "Cyster J.G."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/author | "Cyster J.G."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/author | "Kelly L.M."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/author | "Kelly L.M."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/author | "Yi T."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/author | "Yi T."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/author | "Pereira J.P."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/author | "Pereira J.P."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/pages | "3026-3032"xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/pages | "3026-3032"xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/title | "EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/title | "EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues."xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/21844396 | http://purl.uniprot.org/core/volume | "187"xsd:string |