| http://purl.uniprot.org/citations/21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21845734 | http://www.w3.org/2000/01/rdf-schema#comment | "Human helicase-like transcription factor (HLTF) is a functional homologue of yeast Rad5 that regulates error-free replication through DNA lesions. HLTF promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen (PCNA) that is required for maintaining genomic stability. Here, we identified the deubiquitylating enzyme ubiquitin-specific protease 7 (USP7) as a novel regulator of HLTF stability. We found that USP7 interacted with and stabilized HLTF after genotoxic stress. Furthermore, USP7 mediated deubiquitination significantly prolonged the half-life of HLTF, which in turn increased PCNA polyubiquitination. More intriguingly, silencing of USP7 rendered A549 cells highly sensitive to DNA damage and over-expression of HLTF attenuated this sensitivity. Thus, our results delineate a previously unknown USP7-HLTF-PCNA molecular network controlling DNA damage response."xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcb.23317"xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://purl.uniprot.org/core/author | "Yan L."xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://purl.uniprot.org/core/author | "Han L."xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://purl.uniprot.org/core/author | "Bin L."xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://purl.uniprot.org/core/author | "Ping W.X."xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://purl.uniprot.org/core/author | "Qing P."xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21845734 | http://purl.uniprot.org/core/name | "J Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://purl.uniprot.org/core/pages | "3856-3862"xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://purl.uniprot.org/core/title | "USP7 regulates the stability and function of HLTF through deubiquitination."xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/21845734 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21845734 |
| http://purl.uniprot.org/citations/21845734 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21845734 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGA6-mappedCitation-21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21845734 |
| http://purl.uniprot.org/uniprot/#_B7Z7T5-mappedCitation-21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21845734 |
| http://purl.uniprot.org/uniprot/#_A8K5B6-mappedCitation-21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21845734 |
| http://purl.uniprot.org/uniprot/#_B7Z842-mappedCitation-21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21845734 |
| http://purl.uniprot.org/uniprot/#_B7Z855-mappedCitation-21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21845734 |
| http://purl.uniprot.org/uniprot/#_B7ZAX6-mappedCitation-21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21845734 |
| http://purl.uniprot.org/uniprot/#_Q05BZ6-mappedCitation-21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21845734 |
| http://purl.uniprot.org/uniprot/#_Q05DF7-mappedCitation-21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21845734 |
| http://purl.uniprot.org/uniprot/#_Q05DQ5-mappedCitation-21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21845734 |
| http://purl.uniprot.org/uniprot/#_Q14527-mappedCitation-21845734 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21845734 |