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http://purl.uniprot.org/citations/21846948http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objectives

Obesity is associated with high levels proinflammatory cytokines like tumour necrosis factor alpha (TNF-α), which may play an important role in the genesis of insulin resistance. We evaluated the relationship of -308G/A polymorphism of TNF-α gene with obesity and insulin resistance in Asian Indians in north India.

Methods

This cross-sectional study included 151 apparently healthy individuals (79 males, 72 females) 18-50 yrs of age from New Delhi, India. Body composition by dual-energy x-ray absorptiometry (DEXA) and abdominal fat by magnetic resonance imaging (MRI) were measured. Biochemical measurements included OGTT, lipids, fasting insulin, hs-CRP and TNF-α levels. We analysed -308G/A polymorphism of TNF-α gene and studied its association with obesity and biochemical parameters.

Results

At comparable BMI, abdominal obesity was more prevalent in females (50%) as compared to males (20%). The wild genotype (GG) was present in 78.8%, GA in 17.9%, and AA in 3.3% subjects. Measures of body composition, abdominal fat distribution, lipids, insulin, hs-CRP and TNF-α levels were not influenced by the presence of -308G/A polymorphism. Serum TNF-α levels correlated significantly with fasting insulin in both genders.

Conclusion

TNF-α levels correlate with fasting insulin but not with indicators of body composition in Asian Indians. The -308G/A polymorphism of TNF-α gene is not associated with differences in the serum levels of TNF-α in Asian Indians."xsd:string
http://purl.uniprot.org/citations/21846948http://purl.org/dc/terms/identifier"doi:10.3233/dma-2011-0802"xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/author"Misra A."xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/author"Bhushan B."xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/author"Luthra K."xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/author"Guleria R."xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/author"Pandey R.M."xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/author"Vikram N.K."xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/author"Bhatt S.P."xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/author"Poddar P.K."xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/date"2011"xsd:gYear
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http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/pages"39-46"xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/title"Associations of -308G/A polymorphism of tumor necrosis factor (TNF)-alpha gene and serum TNF-alpha levels with measures of obesity, intra-abdominal and subcutaneous abdominal fat, subclinical inflammation and insulin resistance in Asian Indians in north India."xsd:string
http://purl.uniprot.org/citations/21846948http://purl.uniprot.org/core/volume"31"xsd:string
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