Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/21847627http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21847627http://www.w3.org/2000/01/rdf-schema#comment"

Background

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) polymorphism, which may affect host immune response including cytokines production, is thought to be associated with hepatitis B virus (HBV) infection. This study investigated the associations between CTLA4 polymorphism and serum tumor necrosis factor (TNF)-α and interferon (IFN)-γ levels in patients with chronic HBV infection.

Methods

CTLA4 promoter -318C/T and exon 1 +49A/G polymorphisms and serum TNF-α and IFN-γ levels were determined in 172 patients with chronic HBV infection and 145 healthy controls.

Results

The genotype of CTLA4 -318C/T polymorphism had no association to TNF-α and IFN-γ levels. Serum levels of TNF-α and IFN-γ in chronic HBV patients with +49GG genotype were lower than those with +49AG genotype (p = 0.030 and p = 0.042, respectively), and haplotypes -318C + 49A and -318C + 49G seemed to have no significant effects on TNF-α and IFN-γ levels.

Conclusions

CTLA4 +49GG genotype was associated to lower TNF-α and IFN-γ levels in patients with chronic HBV infection but this association was diminished by haplotype formation with -318C/T alleles, indicating that the influence of CTLA4 -318C/T and +49A/G polymorphisms on the susceptibility and disease progress of chronic HBV infection may not be effectuated by affecting TNF-α and IFN-γ secretion."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.org/dc/terms/identifier"doi:10.1007/s00011-011-0368-8"xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/author"Chen J."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/author"Li Z."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/author"Liu Z."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/author"Li N."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/author"Lv Y."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/author"Duan S."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/author"Zhang G."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/author"Zhu Q."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/author"Han Q."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/name"Inflamm Res"xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/pages"1071-1078"xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/title"Associations between cytotoxic T lymphocyte-associated antigen-4 polymorphisms and serum tumor necrosis factor-alpha and interferon-gamma levels in patients with chronic hepatitis B virus infection."xsd:string
http://purl.uniprot.org/citations/21847627http://purl.uniprot.org/core/volume"60"xsd:string
http://purl.uniprot.org/citations/21847627http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21847627
http://purl.uniprot.org/citations/21847627http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21847627
http://purl.uniprot.org/uniprot/#_A0A0G2YPN5-mappedCitation-21847627http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21847627
http://purl.uniprot.org/uniprot/#_A0A7R8GUN6-mappedCitation-21847627http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21847627
http://purl.uniprot.org/uniprot/#_A0A411D318-mappedCitation-21847627http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21847627
http://purl.uniprot.org/uniprot/#_E9L3G1-mappedCitation-21847627http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21847627
http://purl.uniprot.org/uniprot/#_E9L3G3-mappedCitation-21847627http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21847627
http://purl.uniprot.org/uniprot/#_A0A1U9X8M9-mappedCitation-21847627http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21847627
▶