| http://purl.uniprot.org/citations/21849976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21849976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21849976 | http://www.w3.org/2000/01/rdf-schema#comment | "Evolution can follow predictable genetic trajectories, indicating that discrete environmental shifts can select for reproducible genetic changes. Conspecific individuals are an important feature of an animal's environment, and a potential source of selective pressures. Here we show that adaptation of two Caenorhabditis species to growth at high density, a feature common to domestic environments, occurs by reproducible genetic changes to pheromone receptor genes. Chemical communication through pheromones that accumulate during high-density growth causes young nematode larvae to enter the long-lived but non-reproductive dauer stage. Two strains of Caenorhabditis elegans grown at high density have independently acquired multigenic resistance to pheromone-induced dauer formation. In each strain, resistance to the pheromone ascaroside C3 results from a deletion that disrupts the adjacent chemoreceptor genes serpentine receptor class g (srg)-36 and -37. Through misexpression experiments, we show that these genes encode redundant G-protein-coupled receptors for ascaroside C3. Multigenic resistance to dauer formation has also arisen in high-density cultures of a different nematode species, Caenorhabditis briggsae, resulting in part from deletion of an srg gene paralogous to srg-36 and srg-37. These results demonstrate rapid remodelling of the chemoreceptor repertoire as an adaptation to specific environments, and indicate that parallel changes to a common genetic substrate can affect life-history traits across species."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature10378"xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature10378"xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "Butcher R.A."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "Butcher R.A."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "Ailion M."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "Ailion M."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "Bargmann C.I."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "Bargmann C.I."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "Garrison J.L."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "Garrison J.L."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "McGrath P.T."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/author | "McGrath P.T."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/pages | "321-325"xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/pages | "321-325"xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/title | "Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes."xsd:string |
| http://purl.uniprot.org/citations/21849976 | http://purl.uniprot.org/core/title | "Parallel evolution of domesticated Caenorhabditis species targets pheromone receptor genes."xsd:string |