| http://purl.uniprot.org/citations/21853531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21853531 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21853531 | http://www.w3.org/2000/01/rdf-schema#comment | "Obesity is a well-known risk factor for the development of secondary complications such as type 2 diabetes. However, only a part of the obese population develops secondary metabolic disorders. Here, we identify the transcription factor retinoid-related orphan receptor gamma (RORγ) as a negative regulator of adipocyte differentiation through expression of its newly identified target gene matrix metalloproteinase 3. In vivo differentiation of adipocyte progenitor cells from Rorγ-deficient mice is enhanced and obese Rorγ(-/-) mice show decreased adipocyte sizes. These small adipocytes are highly insulin sensitive, leading to an improved control of circulating free fatty acids. Ultimately, Rorγ(-/-) mice are protected from hyperglycemia and insulin resistance in the state of obesity. In adipose stromal-vascular fraction from obese human subjects, Rorγ expression is correlated with adipocyte size and negatively correlated with adipogenesis and insulin sensitivity. Taken together, our findings identify RORγ as a factor, which controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. RORγ might therefore serve as a novel pharmaceutical target to treat obesity-associated insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.org/dc/terms/identifier | "doi:10.1002/emmm.201100172"xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.org/dc/terms/identifier | "doi:10.1002/emmm.201100172"xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Geiger M."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Geiger M."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Gasperikova D."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Gasperikova D."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Wolfrum C."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Wolfrum C."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Teupser D."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Teupser D."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Nawroth P.P."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Nawroth P.P."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Beaton N."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Beaton N."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Roeder E."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Roeder E."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Rudofsky G."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Rudofsky G."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Ukropec J."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Ukropec J."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Civan B."xsd:string |
| http://purl.uniprot.org/citations/21853531 | http://purl.uniprot.org/core/author | "Civan B."xsd:string |