| http://purl.uniprot.org/citations/21854985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21854985 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous experiments suggest a connection between the N-alpha-acetylation of proteins and sensitivity of cells to apoptotic signals. Here, we describe a biochemical assay to detect the acetylation status of proteins and demonstrate that protein N-alpha-acetylation is regulated by the availability of acetyl-CoA. Because the antiapoptotic protein Bcl-xL is known to influence mitochondrial metabolism, we reasoned that Bcl-xL may provide a link between protein N-alpha-acetylation and apoptosis. Indeed, Bcl-xL overexpression leads to a reduction in levels of acetyl-CoA and N-alpha-acetylated proteins in the cell. This effect is independent of Bax and Bak, the known binding partners of Bcl-xL. Increasing cellular levels of acetyl-CoA by addition of acetate or citrate restores protein N-alpha-acetylation in Bcl-xL-expressing cells and confers sensitivity to apoptotic stimuli. We propose that acetyl-CoA serves as a signaling molecule that couples apoptotic sensitivity to metabolism by regulating protein N-alpha-acetylation."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.06.050"xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Asara J.M."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Daley G.Q."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Cantley L.C."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Gygi S.P."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Liu C.F."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Pan H."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Yang R."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Wagner G."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Yuan J."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Zhai B."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Hyberts S.G."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Locasale J.W."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Seebacher J."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Vander Heiden M.G."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Jang I.H."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Heffron G.J."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Sharfi H."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Yi C.H."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Luithardt H."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/author | "Rodriguez-Mias R."xsd:string |
| http://purl.uniprot.org/citations/21854985 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |