| http://purl.uniprot.org/citations/21855797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21855797 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21855797 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy, the primary recycling pathway of cells, plays a critical role in mitochondrial quality control under normal growth conditions and in the response to cellular stress. The Hsp90-Cdc37 chaperone complex coordinately regulates the activity of select kinases to orchestrate many facets of the stress response. Although both maintain mitochondrial integrity, the relationship between Hsp90-Cdc37 and autophagy has not been well characterized. Ulk1, one of the mammalian homologs of yeast Atg1, is a serine-threonine kinase required for mitophagy. Here we show that the interaction between Ulk1 and Hsp90-Cdc37 stabilizes and activates Ulk1, which in turn is required for the phosphorylation and release of Atg13 from Ulk1, and for the recruitment of Atg13 to damaged mitochondria. Hsp90-Cdc37, Ulk1, and Atg13 phosphorylation are all required for efficient mitochondrial clearance. These findings establish a direct pathway that integrates Ulk1- and Atg13-directed mitophagy with the stress response coordinated by Hsp90 and Cdc37."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2011.06.018"xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2011.06.018"xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Kim D.H."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Thompson C.B."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Thompson C.B."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Kundu M."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Kundu M."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Joshi A."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Joshi A."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Ney P.A."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Ney P.A."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Iyengar R."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Iyengar R."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Yang C.Y."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Yang C.Y."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Youle R.J."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Youle R.J."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Cleveland J.L."xsd:string |
| http://purl.uniprot.org/citations/21855797 | http://purl.uniprot.org/core/author | "Cleveland J.L."xsd:string |