| http://purl.uniprot.org/citations/21855805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21855805 | http://www.w3.org/2000/01/rdf-schema#comment | "Methylation of specific lysine residues in the C terminus of p53 is thought to govern p53-dependent transcription following genotoxic and oncogenic stress. In particular, Set7/9 (KMT7)-mediated monomethylation of human p53 at lysine 372 (p53K372me1) was suggested to be essential for p53 activation in human cell lines. This finding was confirmed in a Set7/9 knockout mouse model (Kurash et al., 2008). In an independent knockout mouse strain deficient in Set7/9, we have investigated its involvement in p53 regulation and find that cells from these mice are normal in their ability to induce p53-dependent transcription following genotoxic and oncogenic insults. Most importantly, we detect no impairment in canonical p53 functions in these mice, indicating that Set7/9-mediated methylation of p53 does not seem to represent a major regulatory event and does not appreciably control p53 activity in vivo."xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2011.08.006"xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/author | "Lin S."xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/author | "Yi L."xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/author | "Rogalski J.C."xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/author | "Kast J."xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/author | "Lehnertz B."xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/author | "Rossi F.M."xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/author | "Schulze F.M."xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/pages | "673-680"xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/title | "p53-dependent transcription and tumor suppression are not affected in Set7/9-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/21855805 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21855805 |
| http://purl.uniprot.org/citations/21855805 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21855805 |
| http://purl.uniprot.org/uniprot/#_D3Z2M5-mappedCitation-21855805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21855805 |
| http://purl.uniprot.org/uniprot/#_Q07813-mappedCitation-21855805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21855805 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GR88-mappedCitation-21855805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21855805 |
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| http://purl.uniprot.org/uniprot/#_A0A165ELP6-mappedCitation-21855805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21855805 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-21855805 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21855805 |