| http://purl.uniprot.org/citations/21857651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21857651 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that regulate genes involved in energy metabolism and inflammation. For biological activity, PPARs require cognate lipid ligands, heterodimerization with retinoic X receptors, and coactivation by PPAR-γ coactivator-1α or PPAR-γ coactivator-1β (PGC-1α or PGC-1β, encoded by Ppargc1a and Ppargc1b, respectively). Here we show that lipolysis of cellular triglycerides by adipose triglyceride lipase (patatin-like phospholipase domain containing protein 2, encoded by Pnpla2; hereafter referred to as Atgl) generates essential mediator(s) involved in the generation of lipid ligands for PPAR activation. Atgl deficiency in mice decreases mRNA levels of PPAR-α and PPAR-δ target genes. In the heart, this leads to decreased PGC-1α and PGC-1β expression and severely disrupted mitochondrial substrate oxidation and respiration; this is followed by excessive lipid accumulation, cardiac insufficiency and lethal cardiomyopathy. Reconstituting normal PPAR target gene expression by pharmacological treatment of Atgl-deficient mice with PPAR-α agonists completely reverses the mitochondrial defects, restores normal heart function and prevents premature death. These findings reveal a potential treatment for the excessive cardiac lipid accumulation and often-lethal cardiomyopathy in people with neutral lipid storage disease, a disease marked by reduced or absent ATGL activity."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.2439"xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Jaeger D."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Schreiber R."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Zimmermann R."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Schweiger M."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Schmidt A."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Haemmerle G."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Lass A."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Schoiswohl G."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Zechner R."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Hoefler G."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Madeo F."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Rulicke T."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Kumari M."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Mayer B."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Trauner M."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Kolb D."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Buttner S."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Radner F.P."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Cinti S."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Schrauwen P."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Kershaw E.E."xsd:string |
| http://purl.uniprot.org/citations/21857651 | http://purl.uniprot.org/core/author | "Eder S."xsd:string |