| http://purl.uniprot.org/citations/21857658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21857658 | http://www.w3.org/2000/01/rdf-schema#comment | "Cortico-thalamo-cortical circuits mediate sensation and generate neural network oscillations associated with slow-wave sleep and various epilepsies. Cortical input to sensory thalamus is thought to mainly evoke feed-forward synaptic inhibition of thalamocortical (TC) cells via reticular thalamic nucleus (nRT) neurons, especially during oscillations. This relies on a stronger synaptic strength in the cortico-nRT pathway than in the cortico-TC pathway, allowing the feed-forward inhibition of TC cells to overcome direct cortico-TC excitation. We found a systemic and specific reduction in strength in GluA4-deficient (Gria4(-/-)) mice of one excitatory synapse of the rhythmogenic cortico-thalamo-cortical system, the cortico-nRT projection, and observed that the oscillations could still be initiated by cortical inputs via the cortico-TC-nRT-TC pathway. These results reveal a previously unknown mode of cortico-thalamo-cortical transmission, bypassing direct cortico-nRT excitation, and describe a mechanism for pathological oscillation generation. This mode could be active under other circumstances, representing a previously unknown channel of cortico-thalamo-cortical information processing."xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.2896"xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/author | "Peng K."xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/author | "Frankel W.N."xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/author | "Deisseroth K."xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/author | "Yizhar O."xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/author | "Bryant A.S."xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/author | "Huguenard J.R."xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/author | "Fenno L."xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/author | "Paz J.T."xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/name | "Nat Neurosci"xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/pages | "1167-1173"xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/title | "A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy."xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/21857658 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21857658 |
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