| http://purl.uniprot.org/citations/21857917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21857917 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis B virus (HBV) infection is one of the major causes of hepatocellular carcinoma (HCC) development. Hepatitis B virus X protein (HBx) is known to play a key role in the development of hepatocellular carcinoma (HCC). Several cellular proteins have been reported to be over-expressed in HBV-associated HCC tissues, but their role in the HBV-mediated oncogenesis remains largely unknown. Here, we explored the effect of the over-expressed cellular protein, a ribosomal protein S3a (RPS3a), on the HBx-induced NF-κB signaling as a critical step for HCC development. The enhancement of HBx-induced NF-κB signaling by RPS3a was investigated by its ability to translocate NF-κB (p65) into the nucleus and the knock-down analysis of RPS3a. Notably, further study revealed that the enhancement of NF-κB by RPS3a is mediated by its novel chaperoning activity toward physiological HBx. The over-expression of RPS3a significantly increased the solubility of highly aggregation-prone HBx. This chaperoning function of RPS3a for HBx is closely correlated with the enhanced NF-κB activity by RPS3a. In addition, the mutational study of RPS3a showed that its N-terminal domain (1-50 amino acids) is important for the chaperoning function and interaction with HBx. The results suggest that RPS3a, via extra-ribosomal chaperoning function for HBx, contributes to virally induced oncogenesis by enhancing HBx-induced NF-κB signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0022258"xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Kwon S.Y."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Kim K.H."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Park Y.K."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Lee H.C."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Seong B.L."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Ryu K."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Choi S.I."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Park E.S."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Lim K.H."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Yang S.I."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/author | "Sung I.K."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/pages | "e22258"xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/title | "RPS3a over-expressed in HBV-associated hepatocellular carcinoma enhances the HBx-induced NF-kappaB signaling via its novel chaperoning function."xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21857917 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21857917 |
| http://purl.uniprot.org/citations/21857917 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21857917 |
| http://purl.uniprot.org/uniprot/#_A0A510GAH8-mappedCitation-21857917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21857917 |
| http://purl.uniprot.org/uniprot/#_B7Z3M5-mappedCitation-21857917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21857917 |
| http://purl.uniprot.org/uniprot/#_A8K4W0-mappedCitation-21857917 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21857917 |