| http://purl.uniprot.org/citations/21857966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21857966 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurodegenration is a pathological hallmark of Alzheimer's disease (AD), but the underlying molecular mechanism remains elusive. Here, we present evidence that reveals a crucial role of Wnt5a signaling in this process. We showed that Wnt5a and its receptor Frizzled-5 (Fz5) were up-regulated in the AD mouse brain, and that beta-amyloid peptide (Aβ), a major constituent of amyloid plaques, stimulated Wnt5a and Fz5 expression in primary cortical cultures; these observations indicate that Wnt5a signaling could be aberrantly activated during AD pathogenesis. In support of such a possibility, we observed that inhibition of Wnt5a signaling attenuated while activation of Wnt5a signaling enhanced Aβ-evoked neurotoxicity, suggesting a role of Wnt5a signaling in AD-related neurodegeneration. Furthermore, we also demonstrated that Aβ-induced neurotoxicity depends on inflammatory processes, and that activation of Wnt5a signaling elicited the expression of proinflammatory cytokines IL-1β and TNF-α whereas inhibition of Wnt5a signaling attenuated the Aβ-induced expression of the cytokines in cortical cultures. Our findings collectively suggest that aberrantly up-regulated Wnt5a signaling is a crucial pathological step that contributes to AD-related neurodegeneration by regulating neuroinflammation."xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0022920"xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/author | "Zhong L."xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/author | "Tang S.J."xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/author | "Huang M."xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/author | "Andersson T."xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/pages | "e22920"xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/title | "WNT5A signaling contributes to Abeta-induced neuroinflammation and neurotoxicity."xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21857966 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21857966 |
| http://purl.uniprot.org/citations/21857966 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21857966 |
| http://purl.uniprot.org/uniprot/P05067#attribution-B87E0C6F357803D3DE4266966D3E8C17 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21857966 |
| http://purl.uniprot.org/uniprot/P05067#attribution-C00E832218DC550C5D6C11A20E3E1D8B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21857966 |
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| http://purl.uniprot.org/uniprot/P18893#attribution-B87E0C6F357803D3DE4266966D3E8C17 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21857966 |
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