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http://purl.uniprot.org/citations/21857973http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21857973http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21857973http://www.w3.org/2000/01/rdf-schema#comment"The Drosophila Ten-m (also called Tenascin-major, or odd Oz (odz)) gene has been associated with a pair-rule phenotype. We identified and characterized new alleles of Drosophila Ten-m to establish that this gene is not responsible for segmentation defects but rather causes defects in motor neuron axon routing. In Ten-m mutants the inter-segmental nerve (ISN) often crosses segment boundaries and fasciculates with the ISN in the adjacent segment. Ten-m is expressed in the central nervous system and epidermal stripes during the stages when the growth cones of the neurons that form the ISN navigate to their targets. Over-expression of Ten-m in epidermal cells also leads to ISN misrouting. We also found that Filamin, an actin binding protein, physically interacts with the Ten-m protein. Mutations in cheerio, which encodes Filamin, cause defects in motor neuron axon routing like those of Ten-m. During embryonic development, the expression of Filamin and Ten-m partially overlap in ectodermal cells. These results suggest that Ten-m and Filamin in epidermal cells might together influence growth cone progression."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0022956"xsd:string
http://purl.uniprot.org/citations/21857973http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0022956"xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Zheng L."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Zheng L."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Wides R."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Wides R."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Bellen H.J."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Bellen H.J."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Justice M.J."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Justice M.J."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Avraham Z."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Avraham Z."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Freger V."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Freger V."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Michelson Y."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Michelson Y."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Venken K.J."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/author"Venken K.J."xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/name"PLoS ONE"xsd:string
http://purl.uniprot.org/citations/21857973http://purl.uniprot.org/core/name"PLoS ONE"xsd:string