| http://purl.uniprot.org/citations/21858133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21858133 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundAcquisition of human immunodeficiency virus type 1 (HIV-1) infection is mediated by a combination of characteristics of the infectious and the susceptible member of a transmission pair, including human behavioral and genetic factors, as well as viral fitness and tropism. Here we report on the impact of established and potential new HLA class I determinants of heterosexual HIV-1 acquisition in the HIV-1-exposed seronegative (HESN) partners of serodiscordant Zambian couples.Methodology/principal findingsWe assessed the relationships of behavioral and clinically documented risk factors, index partner viral load, and host genetic markers to HIV-1 transmission among 568 cohabiting couples followed for at least nine months. We genotyped subjects for three classical HLA class I genes known to influence immune control of HIV-1 infection. From 1995 to December 2006, 240 HESNs seroconverted and 328 remained seronegative. In Cox proportional hazards models, HLA-A*68:02 and the B*42-C*17 haplotype in HESN partners were significantly and independently associated with faster HIV-1 acquisition (relative hazards = 1.57 and 1.55; p = 0.007 and 0.013, respectively) after controlling for other previously established contributing factors in the index partner (viral load and specific class I alleles), in the HESN partner (age, gender), or in the couple (behavioral and clinical risk score). Few if any previously implicated class I markers were associated here with the rate of acquiring infection.Conclusions/significanceA few HLA class I markers showed modest effects on acquisition of HIV-1 subtype C infection in HESN partners of discordant Zambian couples. However, the striking disparity between those few markers and the more numerous, different markers found to determine HIV-1 disease course makes it highly unlikely that, whatever the influence of class I variation on the rate of infection, the mechanism mediating that phenomenon is identical to that involved in disease control."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0023469"xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/author | "Song W."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/author | "He D."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/author | "Hunter E."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/author | "Malhotra R."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/author | "Allen S."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/author | "Kaslow R.A."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/author | "Mulenga J."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/author | "Brill I."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/pages | "e23469"xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/title | "Disparate associations of HLA class I markers with HIV-1 acquisition and control of viremia in an African population."xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21858133 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21858133 |
| http://purl.uniprot.org/citations/21858133 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21858133 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-21858133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21858133 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-21858133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21858133 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-21858133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21858133 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-21858133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21858133 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-21858133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21858133 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-21858133 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21858133 |