| http://purl.uniprot.org/citations/21860022 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21860022 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21860022 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9) are members of the IL-1 family of cytokines. These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1, whereas IL-36Ra (IL-1F5) acts as an IL-36R antagonist (IL-36Ra). In this study, we show that both murine bone marrow-derived dendritic cells (BMDCs) and CD4(+) T lymphocytes constitutively express IL-36R and respond to IL-36α, IL-36β, and IL-36γ. IL-36 induced the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α, and IL-23 by BMDCs with a more potent stimulatory effect than that of other IL-1 cytokines. In addition, IL-36β enhanced the expression of CD80, CD86, and MHC class II by BMDCs. IL-36 also induced the production of IFN-γ, IL-4, and IL-17 by CD4(+) T cells and cultured splenocytes. These stimulatory effects were antagonized by IL-36Ra when used in 100-to 1000-fold molar excess. The immunization of mice with IL-36β significantly and specifically promoted Th1 responses. Our data thus indicate a critical role of IL-36R ligands in the interface between innate and adaptive immunity, leading to the stimulation of T helper responses."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2011-05-356873"xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2011-05-356873"xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Dinh H."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Dinh H."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Rodriguez E."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Rodriguez E."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Sallusto F."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Sallusto F."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Martin P."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Martin P."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Gabay C."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Gabay C."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Sims J.E."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Sims J.E."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Palmer G."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Palmer G."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Lamacchia C."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Lamacchia C."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Ronchi F."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Ronchi F."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Talabot-Ayer D."xsd:string |
| http://purl.uniprot.org/citations/21860022 | http://purl.uniprot.org/core/author | "Talabot-Ayer D."xsd:string |