| http://purl.uniprot.org/citations/21862623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21862623 | http://www.w3.org/2000/01/rdf-schema#comment | "The immune competent abdominal adipose tissue, either stored viscerally [visceral adipose tissue (VAT)] or sc [sc adipose tissue (SAT)], has been identified as a source of IL-1β and IL-18. To become active, the proforms of these cytokines require processing by caspase-1, which itself is mediated by the inflammasome. In this descriptive study, we investigate the expression of inflammasome components and caspase-1 in human fat and determine whether caspase-1 activity contributes to the enhanced inflammatory status of VAT. Paired SAT and VAT biopsies from 10 overweight subjects (body mass index, 25-28 kg/m(2)) were used to study the cellular composition and the intrinsic inflammatory capacity of both adipose tissue depots. The percentage of CD8(+) T cells within the lymphocyte fraction was significantly higher in VAT compared with SAT (41.6 vs. 30.4%; P < 0.05). Adipose tissue cultures showed a higher release of IL-1β (10-fold; P < 0.05), IL-18 (3-fold; P < 0.05), and IL-6 and IL-8 (3-fold, P < 0.05; and 4-fold, P < 0.05, respectively) from VAT compared with SAT that was significantly reduced by inhibiting caspase-1 activity. In addition, caspase-1 activity was 3-fold (P < 0.05) higher in VAT compared with SAT, together with an increase in the protein levels of the inflammasome members apoptosis-associated speck-like protein containing a C-terminal caspase-recruitment domain (2-fold; P < 0.05) and nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (2-fold; nonsignificant). Finally, caspase-1 activity levels were positively correlated with the percentage of CD8(+) T cells present in adipose tissue. Our results show that caspase-1 and nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 inflammasome members are abundantly present in human VAT. The increased intrinsic caspase-1 activity in VAT represents a novel and specific inflammatory pathway that may determine the proinflammatory character of this specific depot."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.org/dc/terms/identifier | "doi:10.1210/en.2010-1480"xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "Koenen T.B."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "de Graaf J."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "Netea M.G."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "Joosten L.A."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "Tack C.J."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "Stienstra R."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "van Tits L.J."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "Stalenhoef A.F."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "Hijmans A."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "van der Vliet J.A."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "Pol J.A."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/author | "van Velzen J.F."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/name | "Endocrinology"xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/pages | "3769-3778"xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/title | "The inflammasome and caspase-1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissue."xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://purl.uniprot.org/core/volume | "152"xsd:string |
| http://purl.uniprot.org/citations/21862623 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21862623 |
| http://purl.uniprot.org/citations/21862623 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21862623 |
| http://purl.uniprot.org/uniprot/#_A8K249-mappedCitation-21862623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21862623 |
| http://purl.uniprot.org/uniprot/#_A8K257-mappedCitation-21862623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21862623 |
| http://purl.uniprot.org/uniprot/#_A0A7L9VV54-mappedCitation-21862623 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21862623 |