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http://purl.uniprot.org/citations/21863050 | http://www.w3.org/2000/01/rdf-schema#comment | "The ubiquitin-proteasome system has numerous crucial roles in physiology and pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases (E3s). Of these, the majority are RING finger and RING finger-related E3s. Many RING finger E3s have roles in processes that are central to the maintenance of genomic integrity and cellular homeostasis, such as the anaphase promoting complex/cyclosome (APC/C), the SKP1-cullin 1-F-box protein (SCF) E3s, MDM2, BRCA1, Fanconi anaemia proteins, CBL proteins, von Hippel-Lindau tumour suppressor (VHL) and SIAH proteins. As a result, many RING finger E3s are implicated in either the suppression or the progression of cancer. This Review summarizes current knowledge in this area."xsd:string |
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http://purl.uniprot.org/citations/21863050 | http://purl.uniprot.org/core/author | "Weissman A.M."xsd:string |
http://purl.uniprot.org/citations/21863050 | http://purl.uniprot.org/core/author | "Lipkowitz S."xsd:string |
http://purl.uniprot.org/citations/21863050 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
http://purl.uniprot.org/citations/21863050 | http://purl.uniprot.org/core/name | "Nat Rev Cancer"xsd:string |
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http://purl.uniprot.org/citations/21863050 | http://purl.uniprot.org/core/title | "RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis."xsd:string |
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