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http://purl.uniprot.org/citations/21865850http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21865850http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

The aim of the study was to characterize the whole cell current of the two-pore domain potassium channel TASK-1 (K2P3) in mouse ventricular cardiomyocytes (I(TASK-1)) and to analyze the cardiac phenotype of the TASK-1(-/-) mice.

Methods and results

We have quantified the ventricular I(TASK-1) current using the blocker A293 and TASK-1(-/-) mice. Surface electrocardiogram recordings of TASK-1(-/-) mice showed a prolonged QTc interval and a broadened QRS complex. The differences in electrocardiograms between wild type and TASK-1(-/-) mice disappeared during sympathetic stimulation of the animals. Quantitative RT-PCR, patch clamp recordings and measurements of hemodynamic performance of TASK-1(-/-) mice revealed no major compensatory changes in ion channel transcription. Action potential recordings of TASK-1(-/-) mouse cardiomyocytes indicated that I(TASK-1) modulates action potential duration. Our in vivo electrophysiological studies showed that isoflurane, which activates TASK-1, slowed heart rate and atrioventricular conduction of wild-type but not of TASK-1(-/-) mice.

Conclusion

The results of an invasive electrophysiological catheter protocol in combination with the observed QRS time prolongation in the surface electrocardiogram point towards a regulatory role of TASK-1 in the cardiac conduction system."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.org/dc/terms/identifier"doi:10.1159/000331715"xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Decher N."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Rinne S."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Sachse F.B."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Daut J."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Li X.T."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Meuth S.G."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Maier S.K."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Aller M.I."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Zuzarte M."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Kaufmann S.G."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Netter M.F."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/author"Wemhoner K."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/name"Cell Physiol Biochem"xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/pages"77-86"xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/title"Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex."xsd:string
http://purl.uniprot.org/citations/21865850http://purl.uniprot.org/core/volume"28"xsd:string
http://purl.uniprot.org/citations/21865850http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21865850
http://purl.uniprot.org/citations/21865850http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21865850
http://purl.uniprot.org/uniprot/#_O35111-mappedCitation-21865850http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21865850
http://purl.uniprot.org/uniprot/#_Q9QX34-mappedCitation-21865850http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21865850
http://purl.uniprot.org/uniprot/O35111http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21865850
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