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http://purl.uniprot.org/citations/21868565http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21868565http://www.w3.org/2000/01/rdf-schema#comment"

Background

Kallikrein-related peptidases (KLKs) have been proposed as potential cancer biomarkers. Contradictions in literature led us to clarify the role of KLK5 as a breast cancer predictor, as well as its association with KLK7 expression.

Patients and methods

Semi-quantitative RT-PCR detected KLKs 5 and 7 in 80 breast tissues, 74 neoplastic and 6 normal. Steroid hormone receptors were quantified in all samples. Associations between KLK5 status and clinicopathological variables, as well as disease-free survival (DFS) and overall survival (OS) of patients were analyzed.

Results

Forty tumor tissues showed high KLK5 expression, which was significantly associated with estrogen receptor status. Significant co-expression of KLKs 5 and 7 was observed in the same cancer samples (p=0.02). Increased KLK5 expression was a statistically significant independent prognostic factor for DFS (p=0.009 univariate analysis and p=0.028 multivariate analysis) and OS of patients (p=0.014, univariate analysis).

Conclusion

Increased KLK5 expression can contribute to the prognosis of DFS and OS of breast cancer patients. KLKs 5 and 7 are co-expressed in breast cancer."xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/author"Scorilas A."xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/author"Talieri M."xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/author"Ardavanis A."xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/author"Apostolaki A."xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/author"Karameris A."xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/author"Devetzi M."xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/author"Prezas P."xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/pages"3093-3100"xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/title"Evaluation of kallikrein-related peptidase 5 expression and its significance for breast cancer patients: association with kallikrein-related peptidase 7 expression."xsd:string
http://purl.uniprot.org/citations/21868565http://purl.uniprot.org/core/volume"31"xsd:string
http://purl.uniprot.org/citations/21868565http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21868565
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