| http://purl.uniprot.org/citations/21871889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21871889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21871889 | http://www.w3.org/2000/01/rdf-schema#comment | "Russell's viper venom factor V (FV) activator (RVV-V) is a thrombin-like proteinase that specifically cleaves the Arg1545-Ser1546 bond of FV. Here we present the crystal structure of RVV-V in complex with the FV14 peptide (residues 1533-1546 of human FV) determined at 1.8Å resolution. The structure reveals multiple interactions between RVV-V and the seven residues, Ile1539 (P(7))-Arg1545 (P(1)), of the cleaved substrate. Comparison with substrate-free structures reveals conformational changes of the RVV-V loops upon substrate binding, suggesting that the multiple interactions are mediated by an induced-fit mechanism. The results provide an explanation for the narrow specificity of RVV-V."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2011.08.022"xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2011.08.022"xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/author | "Miyata T."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/author | "Miyata T."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/author | "Takeda S."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/author | "Takeda S."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/author | "Ben Ammar Y."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/author | "Ben Ammar Y."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/author | "Nakayama D."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/author | "Nakayama D."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/pages | "3020-3025"xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/pages | "3020-3025"xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/title | "Structural basis of coagulation factor V recognition for cleavage by RVV-V."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/title | "Structural basis of coagulation factor V recognition for cleavage by RVV-V."xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/volume | "585"xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://purl.uniprot.org/core/volume | "585"xsd:string |
| http://purl.uniprot.org/citations/21871889 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21871889 |
| http://purl.uniprot.org/citations/21871889 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21871889 |