| http://purl.uniprot.org/citations/21879738 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21879738 | http://www.w3.org/2000/01/rdf-schema#comment | "The Crk and Crk-like (CrkL) adaptor proteins play important roles in numerous signaling pathways, bridging tyrosine kinase substrates to downstream signaling effectors by virtue of their phosphotyrosine-binding SH2 domains and their effector-binding SH3 domains. Critical to understanding the diverse roles of Crk/CrkL is the identification of tissue- and signal-specific tyrosine phosphorylated substrates to which they are recruited and the tissue-specific effector proteins they chaperone into signaling complexes. Crk and CrkL are known biochemically and genetically to be essential mediators of Reelin/Disabled-1 (Dab1) signaling, which governs proper mammalian brain development. Multimeric Reelin clusters its receptors as well as the receptor-bound intracellular scaffolding protein Dab1. Clustering induces Fyn/Src-dependent Dab1 tyrosine phosphorylation, which recruits Crk/CrkL and SH3-bound effectors. Previously, 21 Crk/CrkL-SH3 binding proteins were identified from diverse cell types. We present here the proteomic identification of 101 CrkL-SH3 binding proteins from embryonic murine brain. The identified proteins are enriched in the Crk/CrkL-SH3 binding motif and signaling activities regulating cell adhesion and motility. These results suggest Reelin-induced Dab1 tyrosine phosphorylation may generate a multifaceted signaling scaffold containing a rich array of Crk/CrkL-SH3 binding effectors and may explain a growing diversity of cellular activities suggested to be influenced by Reelin/Dab1 signaling."xsd:string |
| http://purl.uniprot.org/citations/21879738 | http://purl.org/dc/terms/identifier | "doi:10.1021/pr200229a"xsd:string |
| http://purl.uniprot.org/citations/21879738 | http://purl.uniprot.org/core/author | "Ballif B.A."xsd:string |
| http://purl.uniprot.org/citations/21879738 | http://purl.uniprot.org/core/author | "Cheerathodi M."xsd:string |
| http://purl.uniprot.org/citations/21879738 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21879738 | http://purl.uniprot.org/core/name | "J Proteome Res"xsd:string |
| http://purl.uniprot.org/citations/21879738 | http://purl.uniprot.org/core/pages | "4453-4462"xsd:string |
| http://purl.uniprot.org/citations/21879738 | http://purl.uniprot.org/core/title | "Identification of CrkL-SH3 binding proteins from embryonic murine brain: implications for Reelin signaling during brain development."xsd:string |
| http://purl.uniprot.org/citations/21879738 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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