| http://purl.uniprot.org/citations/21880930 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21880930 | http://www.w3.org/2000/01/rdf-schema#comment | "Gentle touch sensation in Caenorhabditis elegans is mediated by the MEC-4/MEC-10 channel complex, which is expressed exclusively in six touch receptor neurons (TRNs). The complex contains two pore-forming subunits, MEC-4 and MEC-10, as well as the accessory subunits MEC-2, MEC-6, and UNC-24. MEC-4 is essential for channel function, but beyond its role as a pore-forming subunit, the functional contribution of MEC-10 to the channel complex and to touch sensation is unclear. We addressed this question using behavioral assays, in vivo electrophysiological recordings from TRNs, and heterologous expression of mutant MEC-10 isoforms. Animals with a deletion in mec-10 showed only a partial loss of touch sensitivity and a modest decrease in the size of the mechanoreceptor current (MRC). In contrast, five previously identified mec-10 alleles acted as recessive gain-of-function alleles that resulted in complete touch insensitivity. Each of these alleles produced a substantial decrease in MRC size and a shift in the reversal potential in vivo. The latter finding indicates that these mec-10 mutations alter the ionic selectivity of the transduction channel in vivo. All mec-10 mutant animals had properly localized channel complexes, indicating that the loss of MRCs was not attributable to a dramatic mislocalization of transduction channels. Finally, electrophysiological examination of heterologously expressed complexes suggests that mutant MEC-10 proteins may affect channel current via MEC-2."xsd:string |
| http://purl.uniprot.org/citations/21880930 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.4580-10.2011"xsd:string |
| http://purl.uniprot.org/citations/21880930 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/21880930 | http://purl.uniprot.org/core/author | "Chalfie M."xsd:string |
| http://purl.uniprot.org/citations/21880930 | http://purl.uniprot.org/core/author | "Goodman M.B."xsd:string |
| http://purl.uniprot.org/citations/21880930 | http://purl.uniprot.org/core/author | "O'Hagan R."xsd:string |
| http://purl.uniprot.org/citations/21880930 | http://purl.uniprot.org/core/author | "Arnadottir J."xsd:string |
| http://purl.uniprot.org/citations/21880930 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21880930 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/21880930 | http://purl.uniprot.org/core/pages | "12695-12704"xsd:string |
| http://purl.uniprot.org/citations/21880930 | http://purl.uniprot.org/core/title | "The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons."xsd:string |
| http://purl.uniprot.org/citations/21880930 | http://purl.uniprot.org/core/volume | "31"xsd:string |
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