| http://purl.uniprot.org/citations/21881584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21881584 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21881584 | http://www.w3.org/2000/01/rdf-schema#comment | "Accumulating evidence indicates that IL-1 family members and Th17 cytokines have a pathogenic role in psoriasis. We investigated the regulatory interactions of the IL-1-like IL-36 cytokine family and the Th17 cytokines in the context of skin inflammation. We observed increased gene expression of all three IL-36 cytokines in a Th17-dominant psoriasis-like animal model. The induction was downregulated by neutralizing IL-22. Expression of the IL-36s was also induced in cultured primary human keratinocytes (KC) by IL-17A and tumor necrosis factor (TNF)-α, and IL-22 synergized with IL-17A and TNF-α. Furthermore, the IL-36s directly induced their own expression and the production of proinflammatory mediators (TNF-α, IL-6, IL-8) in KC. These functions were markedly enhanced with the addition of IL-17A or TNF-α to the cultures. Similarly, IL-36α and IL-36β augmented IL-17A-mediated induction of antibacterial peptides. Finally, we show that the increased gene expression of IL-36 correlated with Th17 cytokines in the lesions of psoriatic patients. Our results indicate that the IL-36 cytokines are not only regulated by Th17 cytokines, but that they themselves can regulate the expression and enhance the function of Th17 cytokines. We propose that a feedback loop between the IL-36 and Th17 cytokines is involved in driving cytokine expression in psoriatic tissues."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2011.234"xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.org/dc/terms/identifier | "doi:10.1038/jid.2011.234"xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Collins M."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Collins M."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Medley Q.G."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Medley Q.G."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Young D.A."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Young D.A."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Ma H.L."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Ma H.L."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Small C."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Small C."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Dunussi-Joannopoulos K."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Dunussi-Joannopoulos K."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Fouser L.A."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Fouser L.A."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Carrier Y."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Carrier Y."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Napierata L."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Napierata L."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Nickerson-Nutter C."xsd:string |
| http://purl.uniprot.org/citations/21881584 | http://purl.uniprot.org/core/author | "Nickerson-Nutter C."xsd:string |