| http://purl.uniprot.org/citations/21883956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21883956 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone marrow kinase in the X chromosome, a member of the Tec family of tyrosine kinases, plays a role in both monocyte/macrophage trafficking as well as cytokine secretion. Although the structures of Tec family kinases Bruton's tyrosine kinase and IL-2-inducible T-cell kinase are known, the crystal structures of other Tec family kinases have remained elusive. We report the X-ray crystal structures of bone marrow kinase in the X chromosome in complex with dasatinib at 2.4 Å resolution and PP2 at 1.9 Å resolution. The bone marrow kinase in the X chromosome structures reveal a typical kinase protein fold; with well-ordered protein conformation that includes an open/extended activation loop and a stabilized DFG-motif rendering the kinase in an inactive conformation. Dasatinib and PP2 bind to bone marrow kinase in the X chromosome in the ATP binding pocket and display similar binding modes to that observed in other Tec and Src protein kinases. The bone marrow kinase in the X chromosome structures identify conformational elements of the DFG-motif that could potentially be utilized to design potent and/or selective bone marrow kinase in the X chromosome inhibitors."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1747-0285.2011.01230.x"xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/author | "Gao M."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/author | "Xie D."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/author | "Ahmed N."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/author | "Burke J."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/author | "Chang C.Y."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/author | "Sack J.S."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/author | "Muckelbauer J."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/author | "Tebben A.J."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/author | "Tino J."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/name | "Chem Biol Drug Des"xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/pages | "739-748"xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/title | "X-ray crystal structure of bone marrow kinase in the x chromosome: a Tec family kinase."xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://purl.uniprot.org/core/volume | "78"xsd:string |
| http://purl.uniprot.org/citations/21883956 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21883956 |
| http://purl.uniprot.org/citations/21883956 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21883956 |
| http://purl.uniprot.org/uniprot/#_P51813-mappedCitation-21883956 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21883956 |
| http://purl.uniprot.org/uniprot/P51813 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21883956 |